p21: is interleukin-1 beta correlated with intra cranial pressure after traumatic brain injury?

traumatic brain injury is a leading cause of disability and death from injury in the world. the interleukin-1 (il-1) is a family of cytokines that act as key mediators of the inflammatory response peripherally and centrally. based on many studies, researchers found that the il-1 is the well-known molecule in relation to acute tbi in the models of both focal and diffuse injuries. the il-1 family includes the closely related agonists il-1α and il-1β. interleukin-1 beta (il-1β) is a pro-inflammatory cytokine with a key role in the inflammatory response following tbi and studies indicate that attenuation of this cytokine improves behavioral outcomes. il-1β is measurable in the serum or csf of healthy individuals. although changes in il-1β expression in csf and serum following injury appear to be small, attempts have been made to correlate il-1β levels with outcome. it have been reported that in severe brain injury patients, high concentrations of il-1β in csf were associated with poor outcome and increased intra cranial pressure.